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The antibiotic activity of the tetracycline compounds of the invention may be determined using the method discussed in Example 2, or by using the in vitro standard broth dilution method described in Waitz, J? Sin embargo, zyban tablete iskustva para pacientes con insuficiencia renal severa (eliminación de creatinina menor a 10 ml/min) se recomienda un ajuste de la dosis a 200 mg 2 veces al día a intervalos de aproximadamente 12 horas.

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